Onco BCG recombinante
Chade DC, Borra RC, Nascimento IP, Villanova FE, Leite LC, Andrade EF, Ramos K, Srougi M, Andrade PM. Immunomodulatory effects of recombinant BCG expressing pertussis toxin on TNF-alpha and IL-10 in a bladder cancer model. J Exp Clin Cancer Res 27, 78, 2008. doi: 10.1186/1756-9966-27-78
Andrade PM, Chade DC, Borra RC, Nascimento IP, Villanova FE, Leite LC, Andrade E, Srougi M. The therapeutic potential of recombinant BCG expressing the antigen S1PT in the intravesical treatment of bladder cancer. Urol Oncol. 28(5): 520-5, 2010. doi: 10.1016/j.urolonc.2008.12.017
Rodriguez, D, Goulart, C, Pagliarone, AC, Silva, E, Cunegundes, P, Nascimento, IP, Borra, RC, Dias, WO, Tagliabue, A, Boraschi, D, Leite, LCC, In vitro evidence of human immune responsiveness shows the improved potential of a recombinant BCG strain for bladder cancer treatment, Frontiers in Immunology, 2019, 10, 1460. doi: 10.3389/fimmu.2019.01460
Vacina de rBCG contra a tuberculose
Nascimento IP, Rodriguez D, Santos CC, Amaral EP, Rofatto HK, Junqueira-Kipnis AP, Gonçalves EDC, D'Império-Lima MR, Hirata MH, Silva CL, Winter N, Gicquel B, Mills KHG, Pizza M, Rappuoli R, Leite LCC. Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis. Sci Rep. 2017, 7(1): 2109. doi: 10.1038/s41598-017-02003-9.
Santos, CC, Rodriguez, D, Kanno AI , Leite, LCC & Nascimento, IP (2019): Recombinant BCG expressing the LTAK63 adjuvant induces increased early and long-term immune responses against Mycobacteria, Hum Vaccin Immunother. 2020;16(3):673-683. doi:10.1080/21645515.2019.1669414.
